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Year : 2017  |  Volume : 6  |  Issue : 2  |  Page : 89-92

Pregnancy outcome of day 3 versus day 5 embryo transfer: A retrospective analysis

1 Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Unit, King Abdul-Aziz Medical City, Riyadh, Saudi Arabia
2 Department of Obstetrics and Gynecology, Ministry of Health, Dammam, Saudi Arabia
3 Assistant Professor of Biostatistics, Department of Epidemiology and Biostatistics College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, KSA

Correspondence Address:
Samaher Alfaraj
Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Unit, King Abdul-Aziz Medical City, P.O. Box 22490, Zip 11426, Riyadh
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.12980/apjr.6.20170208

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Objective: To compare the pregnancy rate between day 3 and day 5 transfer regardless grades of embryos and number of transferred embryo. Methods: Retrospective cohort, a total of seven hundred and four patients met our inclusion criteria, with 411 had day 3 embryo transfer and 293 had day 5 embryo transfer. The patients who were older than 40 years old were excluded. Embryo transfer was carried out in all patients in both transfer groups. Results: Both clinical pregnancy rate and implantation rate did not show any statistically significant difference between the day 3 and day five transfer groups. These were 44% vs. 45% with P=0.82 and 19% vs. 19% with P=0.99 respectively. An increase of miscarriage rate with day 5 embryo transferred compare with day 3 (12.0% vs. 4.4%, P=0.01), but no significant difference was found about biochemical pregnancy rate (P=0.52). Conclusions: Transferring embryo at day 5 may not provide any additional benefit over day 3 transfers to patients. In addition, it increases the risk of miscarriage. Further studies of this issue needed for confirming our findings.

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