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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 6  |  Page : 274-279

Effects of Salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats


1 Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria
2 Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria
3 Department of Internal Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Nigeria

Correspondence Address:
Godwin C Akuodor
Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, P. M. B. 053 Abakaliki
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.246347

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Objective: To evaluate the effect of Salacia lehmbachii (S. lehmbachii) ethanol root bark extract on estrous cycle and sex hormones in female rats. Methods: Forty-eight virgin rats with regular 4-day cycle were grouped into four and each group was further subdivided into ‘a’ and ‘b’ (n=6). Each group was orally treated for 28 days with 2 mL of distilled water (control), ethanol root bark extract of S. lehmbachii in doses of 250, 500 and 750 mg/kg/body weight (groups 2, 3, 4, respectively). Estrous cycle was determined daily using the vaginal smear method. Rats in ‘a’ subgroups were weighed and sacrificed on the 29th day, and blood was collected for serum generation which was used for hormonal assay and sex organs were removed and weighed. Rats in ‘b’ subgroups were discontinued from treatment for 2 weeks and the parameters above were reassessed. Results: The mean length of estrous cycle and duration of diestrous of treated rats were prolonged dose dependently compared to control. The increase was significant (P<0.05) at 500 and 750 mg/kg. The other estrous phases were shortened in the same pattern. Relative weights of sex organs were reduced significantly (P<0.05) at the highest dose. Sex hormones levels were significantly (P<0.05) reduced compared to control. The above changes reverted towards the control values two weeks post treatments. Conclusions: Ethanol root bark extract of S. lehmbachii (high doses) has antifertility effect in female rats as it prolongs the estrous and diestrous cycle, and reduces serum sex hormones levels. The observed alterations were reversible.


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