• Users Online: 5249
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 1  |  Page : 9-15

Assessment of antioxidant status of women with polycystic ovarian syndrome


Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Ekiti State, Nigeria

Correspondence Address:
Olufisayo Grace Oyebanji
Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Ekiti State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.275523

Rights and Permissions

Objective: To determine the antioxidant status of females with polycystic ovarian syndrome. Methods: Blood samples of 85 females (45 newly diagnosed polycystic ovarian syndrome patients and 40 apparently healthy subjects) between 25 and 45 years of age were obtained from Ekiti State University Teaching Hospital, Ado Ekiti, Ekiti State, Nigeria. Spectrophotometry was used to evaluate the plasma concentrations of malondialdehyde, vitamin A, C and E, reduced glutathione and activities of glutathione peroxidase, catalase and superoxide dismutase. Results: The concentrations of malondialdehyde and glutathione peroxidase activity significantly increased (P<0.05) in patients with polycystic ovarian syndrome compared with the healthy controls, while concentrations of reduced glutathione, vitamins A, C, E and activities of catalase and superoxide dismutase of patients with polycystic ovarian syndrome showed significant decrease (P<0.05) compared to the healthy controls. This study showed that oxidative stress may assume a role in the pathogenesis of polycystic ovarian syndrome. There were significant negative correlations between malondialdehyde and superoxide dismutase, catalase (P<0.01) and vitamin A (P<0.05), while there was a significant positive correlation (P<0.01) between malondialdehyde and glutathione peroxidase. In addition, vitamins A (P<0.05), C (P<0.01) and E (P<0.01) showed significant positive correlations with catalase antioxidant enzyme. However, vitamins C and E showed significant positive correlation (P<0.05) among each other. Conclusions: The involvement of antioxidants in the management of polycystic ovarian syndrome may be helpful as secondary therapy to prevent oxidative damage and may be used as a potential approach to overcome metabolic as well as reproductive disorders associated with infertility in polycystic ovarian syndrome.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2408    
    Printed109    
    Emailed2    
    PDF Downloaded304    
    Comments [Add]    
    Cited by others 2    

Recommend this journal