• Users Online: 212
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 5  |  Page : 215-222

Socioeconomic, biological and genetic factors influencing preterm birth


1 Department of Zoology, Biomedical Technology and Human Genetics, School of Sciences, Gujarat University, Ahmedabad, India
2 Department of Integrative Biology, Vellore Institute of Technology, Vellore, India
3 Obstetrics & Gynaecology Department, Superintendent, GMERS Medical College and Hospital, Sola, Ahmedabad, India

Correspondence Address:
Divya Chandel
Department of Zoology, Biomedical Technology and Human Genetics, School of Sciences, Gujarat University, Ahmedabad
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.294663

Rights and Permissions

The etiology of preterm birth is mostly underestimated in developing countries. Current presumptions are that both environmental and genetic factors contribute towards its onset and are responsible for the higher frequency of neonatal deaths. Despite there being considerable scientific data on preterm births across the world, the frequency of its occurrence and threat to the survival of neonates are alarming. It is important that variations among populations should be considered as the socioeconomic status, climatic zones and other genetic, as well as epidemiological factors vary, so as to draw definitive conclusions on the pathogenesis of preterm birth. Predictive biomarkers, prevention and optimum treatment strategies are still being discovered, but with well-designed studies and collaborative efforts, maternal and child healthcare can be prioritized. The purpose of this review is to understand the contributing factors of preterm birth as it is a critical issue and needs in-depth understanding with planned scientific studies to decrease the rate of preterm birth and complication related to it. Furthermore, the review enlists various factors linked to preterm birth viz, high maternal age, psychological state, environmental contaminants, infection, cervical length, addiction, cytokine interaction, preeclampsia, genetic composition, ethnicity, oxidative stress and microRNAs. We have summarized the status of preterm birth, its causes, and future line of work required to prevent mortality of mother and neonate that will help us design successful studies which aim to reduce preterm births effectively.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2746    
    Printed84    
    Emailed0    
    PDF Downloaded258    
    Comments [Add]    

Recommend this journal