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Year : 2022  |  Volume : 11  |  Issue : 2  |  Page : 53-61

A scoping review of SARS-CoV-2 and male infertility: Concerns and future prospects

Medical Technique Department, College of Medical Technique, The Islamic University, Babylon, Iraq

Correspondence Address:
Falah Hasan Obayes AL-Khikani
Medical Technique Department, College of Medical Technique, The Islamic University, Babylon
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2305-0500.341111

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in the blood, urine, facial/anal swabs, semen, and vaginal discharge; all have been shown to contain SARS-CoV-2 RNA. Recent findings have highlighted the prospect of SARS-CoV-2 invading the genital system in addition to other tissues, which might give rise to reproductive concerns. This investigation sheds light on male reproductive tract vulnerability to invasion by SARS-CoV-2 and provides a foundation for further researches into male fertility. Males are infected with COVID-19 at a higher rate than females. As a result, some data suggest that this viral infection might affect the male reproductive system. The probable causes for male genital tract abnormalities in COVID- 19 are: 1) high expression of angiotensin-converting enzyme 2 in the testes; 2) SARS-CoV-2 infection indirectly induces immune response in the testes; 3) SARS-CoV-2 directly damages male genital cells by virus-receptor binding activity; 4) fever in SARS-CoV-2 infected males may cause damages to testicular cells; 5) testosterone level decreased in SAR-CoV-2 infected males; 6) males are more susceptible to COVID-19 than females, which may be due to differences in the physiology of the genital tract. This review seeks to offer some insights into the potential causes of COVID-19 that affect the male reproductive system, as well as future prospect on this issue.

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