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REVIEW ARTICLE
Year : 2022  |  Volume : 11  |  Issue : 3  |  Page : 107-116

Oxidative stress and female reproductive disorder: A review


1 Department of Medical Laboratory Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal-576104, India
2 Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal-576104, India
3 Department of Endocrinology, Dr ALM PGIBMS, Taramani, University of Madras, Chennai, India
4 School of Medicine, Department of Neurology, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, U.S.A, USA
5 Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chennai, 603103, India
6 Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, India

Correspondence Address:
Karkala Sreedhara Ranganath Pai
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.346088

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Oxidative stress arises from an imbalance between the body’s pro-oxidants and antioxidants. Recently, oxidative stress has been proven a contributing factor to many female reproductive disorders including infertility, preeclampsia, endometriosis and polycystic ovarian syndrome. Herein, we review the mechanistic role of oxidative stress in inducing the most common female reproductive disorders. The current review has also highlighted the protective role of vitamin C, necessary for certain female reproductive hormone secretion by the antral follicle and corpus luteum and also essential for collagen production in ovarian tissue remodeling after ovulation, in alleviating oxidative stress and thus improving female reproductive outcomes.


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