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  Indian J Med Microbiol
 

Figure 1: Cross section of the testis of male guinea pigs after 60 days of oral gavage with ethanol extract of Spondias mombin leaves (×400; H & E). A: The control group treated with physiological saline. The arrows depict that the germinal epithelium lining of the seminiferous tubules of the testes of male guinea pigs are within normal histology with different stages of spermatogenesis. B: Male guinea pigs treated with 100 mg/kg body weight of ethanol extract of Spondias mombin leaves. The testicular histoarchitecture is similar to that of physiological saline-treated control guinea pigs. The arrows show that the germinal epithelium lining of the seminiferous tubules of the testes of male guinea pigs is within normal histology with different stages of spermatogenesis. C: Male guinea pigs treated with 250 mg/kg body weight of ethanol extract of Spondias mombin leaves. The arrows indicate mild necrotic changes in the seminiferous tubules with reduction in the number of spermatocytes. D: Male guinea pigs treated with 500 mg/kg body weight of ethanol extract of Spondias mombin leaves. The arrows depict degenerative and necrotic changes in the seminiferous tubules with vacuoles in the germinal epithelium and scanty spermatocytes.

Figure 1: Cross section of the testis of male guinea pigs after 60 days of oral gavage with ethanol extract of <i>Spondias mombin</i> leaves (×400; H & E). A: The control group treated with physiological saline. The arrows depict that the germinal epithelium lining of the seminiferous tubules of the testes of male guinea pigs are within normal histology with different stages of spermatogenesis. B: Male guinea pigs treated with 100 mg/kg body weight of ethanol extract of <i>Spondias mombin</i> leaves. The testicular histoarchitecture is similar to that of physiological saline-treated control guinea pigs. The arrows show that the germinal epithelium lining of the seminiferous tubules of the testes of male guinea pigs is within normal histology with different stages of spermatogenesis. C: Male guinea pigs treated with 250 mg/kg body weight of ethanol extract of <i>Spondias mombin</i> leaves. The arrows indicate mild necrotic changes in the seminiferous tubules with reduction in the number of spermatocytes. D: Male guinea pigs treated with 500 mg/kg body weight of ethanol extract of <i>Spondias mombin</i> leaves. The arrows depict degenerative and necrotic changes in the seminiferous tubules with vacuoles in the germinal epithelium and scanty spermatocytes.