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  Indian J Med Microbiol
 

Figure 1: Microscopic images of ovary sections (hematoxylin and eosin stain; magnification: 100×). A: The normal control group shows normal histological structure like congested vascular space with spindle shaped cells in the medulla. The cortex shows few healthy primary and secondary follicles and the presented corpus luteum contains eosinophilic cytoplasm. B: The PCOS control group shows few follicles with varying sizes and the atretic follicles contain fluid filled antrum. Besides, the corpus luteum is absent. C: The metformin-treated group. D: Gymnema sylvestre-treated group. E: Pergularia daemia-treated group. F: The combination treatment group of Gymnema sylvestre and Pergularia daemia. All the treatment groups (D-F) show the minimal number of cysts, normal healthy follicles, and decreased fluid filled antrum, and also show the presence of corpus luteum. However, the combination treatment group (F) shows better histological changes than other treatment groups and its changes reach almost nearer to the normal control group. CL: corpus luteum; FO: follicles; FC: follicular cyst.

Figure 1: Microscopic images of ovary sections (hematoxylin and eosin stain; magnification: 100×). A: The normal control group shows normal histological structure like congested vascular space with spindle shaped cells in the medulla. The cortex shows few healthy primary and secondary follicles and the presented corpus luteum contains eosinophilic cytoplasm. B: The PCOS control group shows few follicles with varying sizes and the atretic follicles contain fluid filled antrum. Besides, the corpus luteum is absent. C: The metformin-treated group. D: <i>Gymnema</i> sylvestre-treated group. E: <i>Pergularia</i> daemia-treated group. F: The combination treatment group of <i>Gymnema sylvestre</i> and <i>Pergularia daemia</i>. All the treatment groups (D-F) show the minimal number of cysts, normal healthy follicles, and decreased fluid filled antrum, and also show the presence of corpus luteum. However, the combination treatment group (F) shows better histological changes than other treatment groups and its changes reach almost nearer to the normal control group. CL: corpus luteum; FO: follicles; FC: follicular cyst.